RT Journal Article
T1 DDRprot: a database of DNA damage response-related proteins
A1 Andres-Leon, Eduardo
A1 Cases, Ildefonso
A1 Arcas, Aida
A1 Rojas, Ana M.
K1 Double-strand breaks
K1 Evolutionary analysis
K1 Atr inhibitors
K1 Repair
K1 Mechanisms
K1 Network
K1 Focus
K1 Life
AB The DNA Damage Response (DDR) signalling network is an essential system that protects the genome's integrity. The DDRprot database presented here is a resource that integrates manually curated information on the human DDR network and its subpathways. For each particular DDR protein, we present detailed information about its function. If involved in post-translational modifications (PTMs) with each other, we depict the position of the modified residue/s in the three-dimensional structures, when resolved structures are available for the proteins. All this information is linked to the original publication from where it was obtained. Phylogenetic information is also shown, including time of emergence and conservation across 47 selected species, family trees and sequence alignments of homologues. The DDRprot database can be queried by different criteria: pathways, species, evolutionary age or involvement in (PTM). Sequence searches using hidden Markov models can be also used.
PB Oxford univ press
SN 1758-0463
YR 2016
FD 2016-08-29
LK http://hdl.handle.net/10668/18943
UL http://hdl.handle.net/10668/18943
LA en
DS RISalud
RD Apr 18, 2025