RT Journal Article
T1 Effect of physical therapy on bone remodelling in preterm infants: a multicenter randomized controlled clinical trial.
A1 Torró-Ferrero, Galaad
A1 Fernández-Rego, Francisco Javier
A1 Jiménez-Liria, María Rosario
A1 Agüera-Arenas, Juan Jose
A1 Piñero-Peñalver, Jessica
A1 Sánchez-Joya, María Del Mar
A1 Fernández-Berenguer, María Jesús
A1 Rodríguez-Pérez, Mónica
A1 Gomez-Conesa, Antonia
K1 Bone mineralization
K1 Bone resorption
K1 Neonatal intensive care units
K1 Osteogenesis
K1 Osteopenia
K1 Physical therapy modalities
K1 Premature infant
AB Preterm infants have a low level of bone mineralization compared to those born at term, since 80% of calcium incorporation occurs at the end of pregnancy. The purpose of the present study was to investigate the effect of reflex locomotion therapy on bone modeling and growth in preterm infants and to compare its effect with those of other Physiotherapy modalities. A multicentre randomized controlled clinical trial was conducted (02/2016 - 07/2020). 106 preterm infants born at the Virgen de la Arrixaca University Clinical Hospital, the General University Hospital of Elche and the Torrecárdenas University Hospital of Almería, between 26 and 34 weeks with hemodynamic stability, complete enteral nutrition and without any metabolic, congenital, genetic, neurological or respiratory disorders were evaluated for inclusion. Infants were randomly assigned to three groups: one group received reflex locomotion therapy (EGrlt); another group received passive mobilizations with gentle joint compression (EGpmc); and the control group received massage (CG). All treatments were carried out in the neonatal units lasting one month. The main outcome measure was bone formation and resorption measured with bone biomarkers. A mixed ANOVA was used to compare the results of bone biomarkers, and anthropometric measurements. Infants were randomized to EGrlt (n = 38), EGpmc (n = 32), and CG (n = 36). All groups were similar in terms of gender (p = 0.891 female 47.2%), gestational age (M = 30.753, SD = 1.878, p = 0.39) and birth weight (M = 1413.45, SD = 347.36, p = 0.157). At the end of the study, significant differences were found between the groups in their interaction in bone formation, measured with osteocalcin [F (2,35) = 4.92, p = 0.013, ηp2 = 0.043], in benefit of the EGrlt. Reflex locomotion therapy has been effective in improving bone formation, more so than other Physiotherapy modalities. Therefore, reflex locomotion therapy could be considered one of the most effective physiotherapeutic modalities for the prevention and treatment of osteopenia of prematurity. Trial retrospectively registered at ClinicalTrials.gov. First posted on 22/04/2020. NCT04356807 .
YR 2022
FD 2022-06-24
LK http://hdl.handle.net/10668/20287
UL http://hdl.handle.net/10668/20287
LA en
DS RISalud
RD Apr 7, 2025