RT Journal Article
T1 Predictors of poor prognosis in healthy, young, individuals with SARS-CoV-2 infections.
A1 Espejo-Paeres, Carolina
A1 Espliguero, Ramón Arroyo
A1 Uribarri, Aitor
A1 Antón-Huguet, Berta
A1 Romero, Rodolfo
A1 Fernández-Rozas, Inmaculada
A1 Becerra-Muñoz, Víctor Manuel
A1 Alfonso-Rodríguez, Emilio
A1 Huang, Jia
A1 Ortega-Armas, María Elizabeth
A1 Pepe, Martino
A1 González, Adelina
A1 Bertolazzi, Marzia
A1 Cerrato, Enrico
A1 Quezada, Antonio
A1 Raposeiras-Roubin, Sergio
A1 Vedia, Oscar
A1 Feltes-Guzmán, Gisela
A1 Akin, Ibrahim
A1 Carrero-Fernández, Ana
A1 Macaya, Carlos
A1 Estrada, Vicente
A1 Núñez-Gil, Iván J
A1 HOPE COVID-19 investigators, 
K1 COVID-19
K1 Healthy
K1 Lung disease
K1 Mortality
K1 Prognosis
K1 Young
AB To identify predictors of poor prognosis in previously healthy young individuals admitted to hospital with coronavirus disease 2019 (COVID-19). We studied a cohort of patients hospitalized with COVID-19. All patients without co-morbidities, without usual treatments and ≤65 years old were selected from an international registry (HOPE-COVID-19, NCT04334291). We focused on baseline variables-symptoms and signs at admission-to analyse risk factors for poor prognosis. The primary end point was a composite of major adverse clinical events during hospitalization including mortality, mechanical ventilation, high-flow nasal oxygen therapy, prone, sepsis, systemic inflammatory response syndrome and embolic events. Overall, 773 healthy young patients were included. The primary composite end point was observed in 29% (225/773) and the overall mortality rate was 3.6% (28/773). In the combined event group, 75% (168/225) of patients were men and the mean age was 49 (±11) years, whereas in the non-combined event group, the prevalence of male gender was 43% (238/548) and the mean age was 42 (±13) years (p  Major adverse clinical events were unexpectedly high considering the baseline characteristics of the cohort. Signs of respiratory compromise at admission and male gender, were predictive for poor prognosis among young healthy patients hospitalized with COVID-19.
YR 2021
FD 2021-09-30
LK http://hdl.handle.net/10668/22120
UL http://hdl.handle.net/10668/22120
LA en
DS RISalud
RD Apr 12, 2025