RT Journal Article
T1 IL-1β Implications in Type 1 Diabetes Mellitus Progression: Systematic Review and Meta-Analysis.
A1 Cano-Cano, Fatima
A1 Gomez-Jaramillo, Laura
A1 Ramos-Garcia, Pablo
A1 Arroba, Ana I
A1 Aguilar-Diosdado, Manuel
K1 IL-1β
K1 Chronic inflammation
K1 Meta-analysis
K1 Systematic review
K1 Type 1 diabetes mellitus
AB During Type 1 Diabetes Mellitus (T1DM) progression, there is chronic and low-grade inflammation that could be related to the evolution of the disease. We carried out a systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers such as interleukin-1 beta (IL-1β) is significantly different among patients with or without T1DM, in gender, management of the T1DM, detection in several biological fluids, study design, age range, and glycated hemoglobin. We searched PubMed, Embase, Web of Science, and Scopus databases, and 26 relevant studies (2186 with T1DM, 2047 controls) were included. We evaluated the studies’ quality using the Newcastle−Ottawa scale. Meta-analyses were conducted, and heterogeneity and publication bias were examined. Compared with controls, IL-1β determined by immunoassays (pooled standardized mean difference (SMD): 2.45, 95% CI = 1.73 to 3.17; p  7: SMD = 5.43, 95% CI = 3.31−7.56; p = 0.001). Compared with the study design, IL-1β evaluated by ELISA (pooled SMD = 3.29, 95% CI = 2.27 to 4.30, p< 0.001) was significantly elevated in T1DM patients. IL-1β remained significantly higher in patients with a worse management of T1DM and in the early stage of T1DM. IL-1β levels determine the inflammatory environment during T1DM.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-02-25
LK http://hdl.handle.net/10668/21249
UL http://hdl.handle.net/10668/21249
LA en
NO Cano-Cano F, Gómez-Jaramillo L, Ramos-García P, Arroba AI, Aguilar-Diosdado M. IL-1β Implications in Type 1 Diabetes Mellitus Progression: Systematic Review and Meta-Analysis. J Clin Med. 2022 Feb 27;11(5):1303
DS RISalud
RD Apr 19, 2025