TY  - JOUR
AU  - Sin-Chan, Patrick
AU  - Mumal, Iqra
AU  - Suwal, Tannu
AU  - Ho, Ben
AU  - Fan, Xiaolian
AU  - Singh, Irtisha
AU  - Du, Yuchen
AU  - Lu, Mei
AU  - Patel, Neilket
AU  - Torchia, Jonathon
AU  - Popovski, Dean
AU  - Fouladi, Maryam
AU  - Guilhamon, Paul
AU  - Hansford, Jordan R
AU  - Leary, Sarah
AU  - Hoffman, Lindsey M
AU  - Mulcahy Levy, Jean M
AU  - Lassaletta, Alvaro
AU  - Solano-Paez, Palma
AU  - Rivas, Eloy
AU  - Reddy, Alyssa
AU  - Gillespie, G Yancey
AU  - Gupta, Nalin
AU  - Van Meter, Timothy E
AU  - Nakamura, Hideo
AU  - Wong, Tai-Tong
AU  - Ra, Young-Shin
AU  - Kim, Seung-Ki
AU  - Massimi, Luca
AU  - Grundy, Richard G
AU  - Fangusaro, Jason
AU  - Johnston, Donna
AU  - Chan, Jennifer
AU  - Lafay-Cousin, Lucie
AU  - Hwang, Eugene I
AU  - Wang, Yin
AU  - Catchpoole, Daniel
AU  - Michaud, Jean
AU  - Ellezam, Benjamin
AU  - Ramanujachar, Ramya
AU  - Lindsay, Holly
AU  - Taylor, Michael D
AU  - Hawkins, Cynthia E
AU  - Bouffet, Eric
AU  - Jabado, Nada
AU  - Singh, Sheila K
AU  - Kleinman, Claudia L
AU  - Barsyte-Lovejoy, Dalia
AU  - Li, Xiao-Nan
AU  - Dirks, Peter B
AU  - Lin, Charles Y
AU  - Mack, Stephen C
AU  - Rich, Jeremy N
AU  - Huang, Annie
PY  - 2019
DO  - 10.1016/j.ccell.2019.06.002
UR  - http://hdl.handle.net/10668/14229
T2  - Cancer cell
AB  - Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA cluster (C19MC) and enrichment of pluripotency factor LIN28A. Here we investigated C19MC oncogenic...
LA  - en
KW  - C19MC
KW  - ETMR
KW  - LIN28A
KW  - MYCN
KW  - brain tumor
KW  - cell-cycle
KW  - epigenetics
KW  - microRNA
KW  - super-enhancer
KW  - therapeutics
KW  - Biomarkers, Tumor
KW  - Brain Neoplasms
KW  - Cell Cycle
KW  - Cell Transformation, Neoplastic
KW  - Chromosomes, Human, Pair 19
KW  - Chromosomes, Human, Pair 2
KW  - DNA Copy Number Variations
KW  - Enhancer Elements, Genetic
KW  - Epigenesis, Genetic
KW  - Gene Expression Regulation
KW  - Gene Regulatory Networks
KW  - Genetic Association Studies
KW  - Genetic Predisposition to Disease
KW  - Humans
KW  - MicroRNAs
KW  - Models, Biological
KW  - Multigene Family
KW  - N-Myc Proto-Oncogene Protein
KW  - Neoplasms, Germ Cell and Embryonal
KW  - Oncogenes
KW  - RNA-Binding Proteins
TI  - A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.
TY  - research article
VL  - 36
ER  -