RT Journal Article
T1 Tracheal Self-Expandable Metallic Stents: A Comparative Study of Three Different Stents in a Rabbit Model.
A1 Serrano, Carolina
A1 Lostalé, Fernando
A1 Rodríguez-Panadero, Francisco
A1 Blas, Ignacio de
A1 Laborda, Alicia
A1 de Gregorio, Miguel Angel
K1 Airway obstruction
K1 Animal models
K1 Drug-eluting stents
K1 Estenosis traqueal
K1 Experimentación animal
K1 Obstrucción de la vía aérea
K1 Stents
K1 Stents liberadores de fármacos
K1 Tracheal stenosis
AB The objective of this study was to assess tracheal reactivity after the deployment of different self-expandable metal stents (SEMS). Forty female New Zealand rabbits were divided into four groups. Three groups received three different SEMS: steel (ST), nitinol (NiTi), or nitinol drug-eluting stent (DES); the fourth group was the control group (no stent). Stents were deployed percutaneously under fluoroscopic guidance. Animals were assessed by multi-slice, computed tomography (CT) scans, and tracheas were collected for anatomical pathology (AP) study. Data from CT and AP were statistically analyzed and correlated. The DES group had the longest stenosis (20.51±14.08mm vs. 5.84±12.43 and 6.57±6.54mm in NiTi and ST, respectively, day 30; P The ST group developed granulomas and significant stenosis. NiTi was the least reactive stent, while DES caused significant lesions that may be related to drug dosage. This type of DES stent is therefore not recommended for the treatment of tracheobronchial stenosis.
YR 2015
FD 2015-07-02
LK https://hdl.handle.net/10668/27466
UL https://hdl.handle.net/10668/27466
LA en
LA es
DS RISalud
RD Apr 12, 2025