RT Journal Article T1 Guía española para el manejo del asma (GEMA) versión 5.1. Aspectos destacados y controversias. T2 Spanish Asthma Management Guidelines (GEMA) VERSION 5.1. Highlights and Controversies. A1 Plaza, Vicente A1 Alobid, Isam A1 Alvarez, Cesareo A1 Blanco, Marina A1 Ferreira, Jorge A1 Garcia, Gabriel A1 Gomez-Outes, Antonio A1 Gomez, Fernando A1 Hidalgo, Antonio A1 Korta, Javier A1 Molina, Jesus A1 Pellegrini, Francisco Javier A1 Perez, Montserrat A1 Plaza, Javier A1 Praena, Manuel A1 Quirce, Santiago A1 Sanz, Jose K1 Asma K1 Asthma K1 Clinical practice guidelines K1 Consenso K1 Consensus K1 Evidence-based medicine K1 Guía de práctica clínica K1 Medicina basada en la evidencia K1 Area de Gestión Sanitaria Sur de Córdoba AB In this fifth phase of development, the contents of the Spanish Asthma Management Guidelines (GEMA), which include versions 5.0 and 5.1, have undergone a thorough review. The aim here is to set the main changes in context. These could be summarized as follows: DIAGNOSIS: new FENO cut-off and severity classification based on treatment needed to maintain control; INTERMITTENT ASTHMA: a more restrictive concept and treatment extended to include a glucocorticoid/adrenergic combination as needed; MILD ASTHMA: glucocorticoid/adrenergic therapy as needed as an alternative in case of low therapeutic adherence to conventional fixed-dose steroids; SEVERE ASTHMA: readjustment of phenotypes, incorporation of triple therapy in a single inhaler, and criteria for selection of a biologic in severe uncontrolled asthma; OTHERS: specific scoring in childhood asthma, incorporation of certain organizational aspects (care circuits, asthma units, telemedicine), new sections on COVID-19 and nasal polyposis. PB Elsevier YR 2021 FD 2021-05-26 LK http://hdl.handle.net/10668/21988 UL http://hdl.handle.net/10668/21988 LA en LA es NO Plaza V, Alobid I, Alvarez C, Blanco M, Ferreira J, García G, et al. Spanish Asthma Management Guidelines (GEMA) VERSION 5.1. Highlights and Controversies. Arch Bronconeumol. 2022 Feb;58(2):150-158. English, Spanish DS RISalud RD Sep 14, 2025