TY - JOUR AU - Leon-Lopez, Rafael AU - Carcel-Fernandez, Sheila AU - Limia-Perez, Laura AU - Romero-Palacios, Alberto AU - Fernandez-Roldan, Maria Concepcion AU - Aguilar-Alonso, Eduardo AU - Perez-Camacho, Ines AU - Rodriguez-Baño, Jesus AU - Merchante, Nicolas AU - Olalla, Julian AU - Esteban-Moreno, M Angeles AU - Santos, Marta AU - Luque-Pineda, Antonio AU - Torre-Cisneros, Julian PY - 2020 DO - 10.1136/bmjopen-2020-039951 UR - http://hdl.handle.net/10668/16603 T2 - BMJ open AB - About 25% of patients with COVID-19 develop acute respiratory distress syndrome (ARDS) associated with a high release of pro-inflammatory cytokines such as interleukin-6 (IL-6). The aim of the SARICOR study is to demonstrate that early administration... LA - en PB - BMJ Group KW - Adult intensive & critical care KW - Infectious diseases KW - Internal medicine KW - Virology KW - Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz KW - Area de Gestión Sanitaria Sur de Córdoba KW - Área de Gestión Sanitaria Sur de Sevilla KW - Adolescent KW - Adult KW - Aged KW - Antibodies, monoclonal, humanized KW - Betacoronavirus KW - COVID-19 KW - Clinical trials, phase II as topic KW - Coronavirus infections KW - Cytokine release syndrome KW - Female KW - Fibrin fibrinogen degradation products KW - Humans KW - Interleukin-6 KW - Male KW - Middle aged KW - Multicenter studies as topic KW - Pandemics KW - Pneumonia, viral KW - Randomized controlled trials as topic KW - Respiration, artificial KW - Respiratory distress syndrome KW - SARS-CoV-2 KW - Young adult KW - COVID-19 drug treatment TI - Efficacy and safety of early treatment with sarilumab in hospitalised adults with COVID-19 presenting cytokine release syndrome (SARICOR STUDY): protocol of a phase II, open-label, randomised, multicentre, controlled clinical trial. TY - research article VL - 10 ER -