TY - JOUR AU - Gil-Ocaña, Violeta AU - Jimenez, Isabel M. AU - Mayorga, Cristobalina AU - Doña, Inmaculada AU - Céspedes, Jose Antonio AU - Montañez, Maria I. AU - Vida, Yolanda AU - Torres, Maria J. AU - Perez-Inestrosa, Ezequiel PY - 2021 DO - 10.3389/fimmu.2021.750109 UR - http://hdl.handle.net/10668/3456 T2 - Frontiers in Immunology AB - β-lactam antibiotics (BLs) are the drugs most frequently involved in drug hypersensitivity reactions. However, current in vitro diagnostic tests have limited sensitivity, partly due to a poor understanding of in vivo drug-protein conjugates that both... LA - en PB - Frontiers KW - Dendrimeric antigen KW - Silica nanoparticles KW - Biepitope nanocomposites KW - Diagnostic test KW - Drug allergy KW - Penicillins KW - Specific IgE KW - Aprobación de pruebas de diagnóstico KW - Hipersensibilidad a las drogas KW - Penicilinas KW - Medical Subject Headings::Persons::Persons::Age Groups::Adolescent KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors:: KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens KW - Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Dendrimers KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Reproductive Control Agents::Fertility Agents::Fertility Agents, Female KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin E KW - Medical Subject Headings::Persons::Persons::Men::Nurses, Male KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged KW - Medical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles KW - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Silicon Compounds::Silicon Dioxide KW - Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Minerals::Silicon Dioxide KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adult TI - Multiepitope Dendrimeric Antigen-Silica Particle Composites as Nano-Based Platforms for Specific Recognition of IgEs TY - research article ER -