RT Journal Article
T1 Brain Functional Connectivity Is Modified by a Hypocaloric Mediterranean Diet and Physical Activity in Obese Women
A1 Garcia-Casares, Natalia
A1 Bernal-Lopez, Maria R.
A1 Roe-Vellve, Nuria
A1 Gutierrez-Bedmar, Mario
A1 Fernandez-Garcia, Jose C.
A1 Garcia-Arnes, Juan A.
A1 Ramos-Rodriguez, Jose R.
A1 Alfaro, Francisco
A1 Santamaria-Fernandez, Sonia
A1 Steward, Trevor
A1 Jimenez-Murcia, Susana
A1 Garcia-Garcia, Isabel
A1 Valdivielso, Pedro
A1 Fernandez-Aranda, Fernando
A1 Tinahones, Francisco J.
A1 Gomez-Huelgas, Ricardo
K1 Mediterranean diet
K1 physical activity
K1 connectivity
K1 obesity
K1 inferior parietal lobe
K1 temporal lobe
K1 insula
K1 prefrontal cortex
K1 posterior cingulate
K1 somatosensory cortex
K1 functional MRI
K1 resting state
AB Functional magnetic resonance imaging (fMRI) in the resting state has shown altered brain connectivity networks in obese individuals. However, the impact of a Mediterranean diet on cerebral connectivity in obese patients when losing weight has not been previously explored. The aim of this study was to examine the connectivity between brain structures before and six months after following a hypocaloric Mediterranean diet and physical activity program in a group of sixteen obese women aged 46.31 +/- 4.07 years. Before and after the intervention program, the body mass index (BMI) (kg/m(2)) was 38.15 +/- 4.7 vs. 34.18 +/- 4.5 (p< 0.02), and body weight (kg) was 98.5 ± 13.1 vs. 88.28 ± 12.2 (p < 0.03). All subjects underwent a pre- and post-intervention fMRI under fasting conditions. Functional connectivity was assessed using seed-based correlations. After the intervention, we found decreased connectivity between the left inferior parietal cortex and the right temporal cortex (p < 0.001), left posterior cingulate (p < 0.001), and right posterior cingulate (p < 0.03); decreased connectivity between the left superior frontal gyrus and the right temporal cortex (p < 0.01); decreased connectivity between the prefrontal cortex and the somatosensory cortex (p < 0.025); and decreased connectivity between the left and right posterior cingulate (p < 0.04). Results were considered significant at a voxel-wise threshold of p ≤ 0.05, and a cluster-level family-wise error correction for multiple comparisons of p ≤ 0.05. In conclusion, functional connectivity between brain structures involved in the pathophysiology of obesity (the inferior parietal lobe, posterior cingulate, temporo-insular cortex, prefrontal cortex) may be modified by a weight loss program including a Mediterranean diet and physical exercise.
PB MDPI
YR 2017
FD 2017-07-01
LK http://hdl.handle.net/10668/19315
UL http://hdl.handle.net/10668/19315
LA en
NO García-Casares N, Bernal-López MR, Roé-Vellvé N, Gutiérrez-Bedmar M, Fernández-García JC, García-Arnés JA, et al. Brain Functional Connectivity Is Modified by a Hypocaloric Mediterranean Diet and Physical Activity in Obese Women. Nutrients. 2017 Jul 1;9(7):685
NO This study was supported by the Instituto de Salud Carlos III (FIS PI12/01373) and by the University of Málaga.
DS RISalud
RD Apr 5, 2025