RT Journal Article
T1 Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis.
A1 Diaz-Cordovés Rego, Gisela
A1 Núñez-Cuadros, Esmeralda
A1 Mena-Vázquez, Natalia
A1 Aguado Henche, Soledad
A1 Galindo-Zavala, Rocío
A1 Manrique-Arija, Sara
A1 Martín-Pedraz, Laura
A1 Redondo-Rodríguez, Rocio
A1 Godoy-Navarrete, Francisco Javier
A1 Fernández-Nebro, Antonio
K1 adiposity
K1 inflammatory disease activity
K1 juvenile idiopathic arthritis
AB To identify factors associated with the higher proportion of fatty tissue and overweight/obesity observed in patients with juvenile idiopathic arthritis (JIA). We performed a cross-sectional study of 80 JIA patients aged 4-15 years with 80 age- and sex-matched healthy controls. Body composition was assessed using dual-energy x-ray absorptiometry. The 27-joint Juvenile Arthritis Disease Activity score (JADAS27) was calculated. Two multivariate models were constructed to identify factors associated with overweight/obesity and fat mass index (FMI). No differences were found between cases and controls in body mass index (BMI) or body composition. However, compared with controls, patients with a high inflammatory activity (JADAS27 > 4.2 for oligoarticular JIA or >8.5 for polyarticular disease) had higher values for BMI (p = 0.006); total fat mass (p = 0.003); FMI (p = 0.001); and fat in the legs (p = 0.001), trunk (p = 0.001), and arms (p = 0.002). The factors associated with overweight/obesity in patients were the duration of therapy with biological drugs, measured in months (OR [95% CI] = 1.12 [1.02-1.04]; p = 0.037), and physical activity (OR [95% CI] = 0.214 [0.07-0.68]; p = 0.010), while the factors associated with FMI were age (β [95% CI] = 0.30 [0.17-1.41]; p = 0.014), JADAS27 (β [95% CI] = 0.45 [0.16-1.08]; p = 0.009), and physical activity (β [95% CI] = -0.22 [-5.76 to 0.29]; p = 0.031). Our study revealed no differences between JIA patients with well-controlled disease and low disability and the healthy population in BMI or body composition. Furthermore, the association observed between inflammatory activity and adiposity could be responsible for poorer clinical course.
SN 2077-0383
YR 2021
FD 2021-08-31
LK https://hdl.handle.net/10668/26111
UL https://hdl.handle.net/10668/26111
LA en
DS RISalud
RD Apr 17, 2025