%0 Journal Article
%A Diaz-Cordovés Rego, Gisela
%A Núñez-Cuadros, Esmeralda
%A Mena-Vázquez, Natalia
%A Aguado Henche, Soledad
%A Galindo-Zavala, Rocío
%A Manrique-Arija, Sara
%A Martín-Pedraz, Laura
%A Redondo-Rodríguez, Rocio
%A Godoy-Navarrete, Francisco Javier
%A Fernández-Nebro, Antonio
%T Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis.
%D 2021
%@ 2077-0383
%U https://hdl.handle.net/10668/26111
%X To identify factors associated with the higher proportion of fatty tissue and overweight/obesity observed in patients with juvenile idiopathic arthritis (JIA). We performed a cross-sectional study of 80 JIA patients aged 4-15 years with 80 age- and sex-matched healthy controls. Body composition was assessed using dual-energy x-ray absorptiometry. The 27-joint Juvenile Arthritis Disease Activity score (JADAS27) was calculated. Two multivariate models were constructed to identify factors associated with overweight/obesity and fat mass index (FMI). No differences were found between cases and controls in body mass index (BMI) or body composition. However, compared with controls, patients with a high inflammatory activity (JADAS27 > 4.2 for oligoarticular JIA or >8.5 for polyarticular disease) had higher values for BMI (p = 0.006); total fat mass (p = 0.003); FMI (p = 0.001); and fat in the legs (p = 0.001), trunk (p = 0.001), and arms (p = 0.002). The factors associated with overweight/obesity in patients were the duration of therapy with biological drugs, measured in months (OR [95% CI] = 1.12 [1.02-1.04]; p = 0.037), and physical activity (OR [95% CI] = 0.214 [0.07-0.68]; p = 0.010), while the factors associated with FMI were age (β [95% CI] = 0.30 [0.17-1.41]; p = 0.014), JADAS27 (β [95% CI] = 0.45 [0.16-1.08]; p = 0.009), and physical activity (β [95% CI] = -0.22 [-5.76 to 0.29]; p = 0.031). Our study revealed no differences between JIA patients with well-controlled disease and low disability and the healthy population in BMI or body composition. Furthermore, the association observed between inflammatory activity and adiposity could be responsible for poorer clinical course.
%K adiposity
%K inflammatory disease activity
%K juvenile idiopathic arthritis
%~