RT Journal Article
T1 Variation of transaminases, HCV-RNA levels and Th1/Th2 cytokine production during the post-partum period in pregnant women with chronic hepatitis C.
A1 Ruiz-Extremera, Angeles
A1 Muñoz-Gámez, José Antonio
A1 Abril-Molina, Ana
A1 Salmerón-Ruiz, María Angustias
A1 Muñoz-de-Rueda, Paloma
A1 Pavón-Castillero, Esther José
A1 Quiles-Pérez, Rosa
A1 Carazo, Angel
A1 Gila, Ana
A1 Jimenez-Ruiz, Sergio Manuel
A1 Casado, Jorge
A1 Martín, Ana Belén
A1 Sanjuán-Núñez, Laura
A1 Ocete-Hita, Esther
A1 López Viota, Julián
A1 León, Josefa
A1 Salmerón, Javier
K1 Interleucinas
K1 ARN Viral
K1 Alanina Transaminasa
K1 Período de Postparto
AB This study analyses the evolution of liver disease in women with chronic hepatitis C during the third trimester of pregnancy and the post-partum period, as a natural model of immune modulation and reconstitution. Of the 122 mothers recruited to this study, 89 were HCV-RNA+ve/HIV-ve and 33 were HCV-RNA-ve/HIV-ve/HCVantibody+ve and all were tested during the third trimester of pregnancy, at delivery and post-delivery. The HCV-RNA+ve mothers were categorized as either Type-A (66%), with an increase in ALT levels in the post-partum period (>40 U/L; P<0.001) or as Type-B (34%), with no variation in ALT values. The Type-A mothers also presented a significant decrease in serum HCV-RNA levels in the post-delivery period (P<0.001) and this event was concomitant with an increase in Th1 cytokine levels (INFγ, P = 0.04; IL12, P = 0.01 and IL2, P = 0.01). On the other hand, the Type-B mothers and the HCV-RNA-ve women presented no variations in either of these parameters. However, they did present higher Th1 cytokine levels in the partum period (INFγ and IL2, P<0.05) than both the Type-A and the HCV-RNA-ve women. Cytokine levels at the moment of delivery do not constitute a risk factor associated with HCV vertical transmission. It is concluded that differences in the ALT and HCV-RNA values observed in HCV-RNA+ve women in the postpartum period might be due to different ratios of Th1 cytokine production. In the Type-B women, the high partum levels of Th1 cytokines and the absence of post-partum variation in ALT and HCV-RNA levels may be related to permanent Th1 cytokine stimulation.
PB Public Library of Science
YR 2013
FD 2013-10-10
LK http://hdl.handle.net/10668/1771
UL http://hdl.handle.net/10668/1771
LA en
NO Ruiz-Extremera A, Muñoz-Gámez JA, Abril-Molina A, Salmerón-Ruiz MA, Muñoz-de-Rueda P, Pavón-Castillero EJ, et al. Variation of transaminases, HCV-RNA levels and Th1/Th2 cytokine production during the post-partum period in pregnant women with chronic hepatitis C. PLoS ONE. 2013; 8(10):e75613
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 5, 2025