RT Journal Article
T1 Asthma-COPD overlap is not a homogeneous disorder: further supporting data
A1 Perez-de-Llano, Luis
A1 Cosio, Borja G.
A1 CHACOS Study Grp, 
K1 Eosinophils
K1 Periostin
K1 COPD
K1 Asthma
K1 Asthma-COPD overlap
K1 ACO
K1 Disease
AB Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-alpha, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions.
PB Biomed central ltd
SN 1465-993X
YR 2017
FD 2017-11-02
LK https://hdl.handle.net/10668/27329
UL https://hdl.handle.net/10668/27329
LA en
DS RISalud
RD Apr 7, 2025