RT Generic
T1 Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate
A1 Ortega, Angeles
A1 Berna, Genoveva
A1 Rojas, Anabel
A1 Martin, Franz
A1 Soria, Bernat
K1 Type 2 diabetes
K1 nutrients
K1 nutrigenetic
K1 nutrigenomic
K1 epigenetic
K1 pancreatic -cell
K1 Chain amino-acids
K1 High-fat diet
K1 Beta-cell function
K1 Impaired fasting glucose
K1 Embryonic stem-cells
K1 Proliferator-activated receptor
K1 Dose-response metaanalysis
K1 Vitamin-c supplementation
K1 7-like 2 gene
K1 Nf-kappa-b
AB Consistent evidence from both experimental and human studies indicates that Type 2 diabetes mellitus (T2DM) is a complex disease resulting from the interaction of genetic, epigenetic, environmental, and lifestyle factors. Nutrients and dietary patterns are important environmental factors to consider in the prevention, development and treatment of this disease. Nutritional genomics focuses on the interaction between bioactive food components and the genome and includes studies of nutrigenetics, nutrigenomics and epigenetic modifications caused by nutrients. There is evidence supporting the existence of nutrient-gene and T2DM interactions coming from animal studies and family-based intervention studies. Moreover, many case-control, cohort, cross-sectional cohort studies and clinical trials have identified relationships between individual genetic load, diet and T2DM. Some of these studies were on a large scale. In addition, studies with animal models and human observational studies, in different countries over periods of time, support a causative relationship between adverse nutritional conditions during in utero development, persistent epigenetic changes and T2DM. This review provides comprehensive information on the current state of nutrient-gene interactions and their role in T2DM pathogenesis, the relationship between individual genetic load and diet, and the importance of epigenetic factors in influencing gene expression and defining the individual risk of T2DM.
PB Mdpi
SN 1661-6596
YR 2017
FD 2017-06-01
LK http://hdl.handle.net/10668/19277
UL http://hdl.handle.net/10668/19277
LA en
DS RISalud
RD Apr 12, 2025