RT Journal Article
T1 Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease
A1 Puentes-Pardo, Jose D.
A1 Moreno-SanJuan, Sara
A1 Carazo, Ángel
A1 León, Josefa
K1 Heme oxygenase
K1 Gastrointestinal tract
K1 Cancer
K1 Diabetes
K1 Pancreatitis
K1 Inflammatory bowel disease
K1 Peptic ulcer disease
K1 Fatty liver disease
K1 Ferroptosis
K1 Hemo-oxigenasa 1
K1 Tracto gastrointestinal
K1 Neoplasias
K1 Enfermedades inflamatorias del intestino
K1 Úlcera péptica
K1 Enfermedad del hígado graso no alcohólico
K1 Diabetes mellitus
AB Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin. HO-1, a stress inducible enzyme, is considered as an anti-oxidative and cytoprotective agent. As many studies suggest, HO-1 is highly expressed in the gastrointestinal tract where it is involved in the response to inflammatory processes, which may lead to several diseases such as pancreatitis, diabetes, fatty liver disease, inflammatory bowel disease, and cancer. In this review, we highlight the pivotal role of HO-1 and its downstream effectors in the development of disorders and their beneficial effects on the maintenance of the gastrointestinal tract health. We also examine clinical trials involving the therapeutic targets derived from HO-1 system for the most common diseases of the digestive system.
PB MDPI
YR 2020
FD 2020-12-02
LK http://hdl.handle.net/10668/3541
UL http://hdl.handle.net/10668/3541
LA en
NO Puentes-Pardo JD, Moreno-SanJuan S, Carazo Á, León J. Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease. Antioxidants (Basel). 2020 Dec 2;9(12):1214
DS RISalud
RD Apr 10, 2025