TY - JOUR AU - Fernandez, Oscar PY - 2017 DO - 10.1016/j.msard.2017.07.003 UR - http://hdl.handle.net/10668/11710 T2 - Multiple sclerosis and related disorders AB - Aggressive, highly active, or rapidly evolving severe relapsing-remitting multiple sclerosis (RRMS) is characterized by frequent relapses and active disease on magnetic resonance imaging, ultimately leading to a high risk for rapid disability... LA - en PB - Elsevier KW - Disease-modifying therapy KW - High-efficacy disease-modifying therapy KW - High-risk multiple sclerosis KW - Relapsing-remitting multiple sclerosis KW - Alemtuzumab KW - Antineoplastic Agents KW - Clinical Trials as Topic KW - Cyclophosphamide KW - Disease Progression KW - Fingolimod Hydrochloride KW - Humans KW - Immunologic Factors KW - Immunosuppressive Agents KW - Mitoxantrone KW - Multiple Sclerosis, Relapsing-Remitting KW - Natalizumab KW - Precision Medicine KW - Risk Assessment KW - Risk Factors KW - Treatment Outcome TI - Is there a change of paradigm towards more effective treatment early in the course of apparent high-risk MS? TY - research article VL - 17 ER -