RT Journal Article
T1 Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis
A1 Coca Prieto, Inmaculada
A1 Valdivielso Felices, Pedro
A1 Olivecrona, Gunilla
A1 Ariza, María José
A1 Rioja, José
A1 Font-Ugalde, Pilar
A1 García Arias, Carlota
A1 González Santos, Pedro
K1 Apolipoproteína C-II
K1 Apolipoproteínas A
K1 Apolipoproteínas E
K1 Triglicéridos
K1 Lipoproteína Lipasa
K1 Adulto
K1 Estudios de Casos y Controles
K1 Femenino
K1 Predisposición Genética a la Enfermedad
K1 Humanos
K1 Hipertrigliceridemia
K1 Hígado
K1 Masculino
K1 Mediana Edad
K1 Pancreatitis
K1 Factores de Riesgo
K1 Enfermedad Aguda
AB BACKGROUNDSevere hypertriglyceridaemia due to chylomicronemia may trigger an acute pancreatitis. However, the basic underlying mechanism is usually not well understood. We decided to analyze some proteins involved in the catabolism of triglyceride-rich lipoproteins in patients with severe hypertriglyceridaemia.METHODSTwenty-four survivors of acute hypertriglyceridaemic pancreatitis (cases) and 31 patients with severe hypertriglyceridaemia (controls) were included. Clinical and anthropometrical data, chylomicronaemia, lipoprotein profile, postheparin lipoprotein lipase mass and activity, hepatic lipase activity, apolipoprotein C II and CIII mass, apo E and A5 polymorphisms were assessed.RESULTSOnly five cases were found to have LPL mass and activity deficiency, all of them thin and having the first episode in childhood. No cases had apolipoprotein CII deficiency. No significant differences were found between the non-deficient LPL cases and the controls in terms of obesity, diabetes, alcohol consumption, drug therapy, gender distribution, evidence of fasting chylomicronaemia, lipid levels, LPL activity and mass, hepatic lipase activity, CII and CIII mass or apo E polymorphisms. However, the SNP S19W of apo A5 tended to be more prevalent in cases than controls (40% vs. 23%, NS).CONCLUSIONPrimary defects in LPL and C-II are rare in survivors of acute hypertriglyceridaemic pancreatitis; lipase activity measurements should be restricted to those having their first episode during childhood.
PB BIOMED CENTRAL LTD
YR 2009
FD 2009-06-17
LK http://hdl.handle.net/10668/825
UL http://hdl.handle.net/10668/825
LA en
NO Coca-Prieto I, Valdivielso P, Olivecrona G, Ariza MJ, Rioja J, Font-Ugalde P, et al. Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis. BMC Gastroenterol; 9:46
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 10, 2025