RT Journal Article
T1 Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity.
A1 Fontalba-Romero, Maria I
A1 Lopez-Enriquez, Soledad
A1 Lago-Sampedro, Ana
A1 Garcia-Escobar, Eva
A1 Pastori, Ricardo L
A1 Dominguez-Bendala, Juan
A1 Alvarez-Cubela, Silvia
A1 Valdes, Sergio
A1 Rojo, Gemma
A1 Garcia-Fuentes, Eduardo
A1 Labajos-Manzanares, Maria T
A1 García-Serrano, Sara
K1 Mediterranean diet
K1 Metabolic syndrome
K1 miRNA
K1 Morbid obesity
K1 Type 2 diabetes mellitus
AB The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.
PB MDPI
YR 2021
FD 2021-01-29
LK http://hdl.handle.net/10668/17155
UL http://hdl.handle.net/10668/17155
LA en
NO Fontalba-Romero MI, Lopez-Enriquez S, Lago-Sampedro A, García-Escobar E, Pastori RL, Domínguez-Bendala J, et al. Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity. Nutrients. 2021 Jan 29;13(2):436
NO This work was supported in part by a grant from the Instituto de Salud Carlos III (PI18/01165) (Spain) and the Consejería de Salud de la Junta de Andalucía (PI-0337-2016) (Spain). This study has been co-funded by FEDER funds (“A way to make Europe”) (“Andalucía se mueve con Europa”).
DS RISalud
RD Apr 8, 2025