%0 Journal Article
%A Fontalba-Romero, Maria I
%A Lopez-Enriquez, Soledad
%A Lago-Sampedro, Ana
%A Garcia-Escobar, Eva
%A Pastori, Ricardo L
%A Dominguez-Bendala, Juan
%A Alvarez-Cubela, Silvia
%A Valdes, Sergio
%A Rojo, Gemma
%A Garcia-Fuentes, Eduardo
%A Labajos-Manzanares, Maria T
%A García-Serrano, Sara
%T Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity.
%D 2021
%U http://hdl.handle.net/10668/17155
%X The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.
%K Mediterranean diet
%K Metabolic syndrome
%K miRNA
%K Morbid obesity
%K Type 2 diabetes mellitus
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