RT Journal Article
T1 Metabotypes of response to bariatric surgery independent of the magnitude of weight loss.
A1 Palau-Rodriguez, Magali
A1 Tulipani, Sara
A1 Marco-Ramell, Anna
A1 Miñarro, Antonio
A1 Jáuregui, Olga
A1 Sanchez-Pla, Alex
A1 Ramos-Molina, Bruno
A1 Tinahones, Francisco J
A1 Andres-Lacueva, Cristina
AB Bariatric surgery is considered the most efficient treatment for morbid obesity and its related diseases. However, its role as a metabolic modifier is not well understood. We aimed to determine biosignatures of response to bariatric surgery and elucidate short-term metabolic adaptations. We used a LC- and FIA-ESI-MS/MS approach to quantify acylcarnitines, (lyso)phosphatidylcholines, sphingomyelins, amino acids, biogenic amines and hexoses in serum samples of subjects with morbid obesity (n = 39) before and 1, 3 and 6 months after bariatric surgery. K-means cluster analysis allowed to distinguish metabotypes of response to bariatric surgery. For the first time, global metabolic changes following bariatric surgery independent of the baseline health status of the subjects have been revealed. We identify two metabolic phenotypes (metabotypes) at the interval 6 months-baseline after surgery, which presented differences in the levels of compounds of urea metabolism, gluconeogenic precursors and (lyso)phospholipid particles. Clinically, metabotypes were different in terms of the degree of improvement in insulin resistance, cholesterol, low-density lipoproteins and uric acid independent of the magnitude of weight loss. This study opens new perspectives and new hypotheses on the metabolic benefits of bariatric surgery and understanding of the biology of obesity and its associated diseases.
YR 2018
FD 2018-06-01
LK http://hdl.handle.net/10668/12528
UL http://hdl.handle.net/10668/12528
LA en
DS RISalud
RD Apr 7, 2025