RT Journal Article
T1 Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
A1 Fernandez de Larrea-Baz, Nerea
A1 Michel, Angelika
A1 Romero, Beatriz
A1 Perez-Gomez, Beatriz
A1 Moreno, Victor
A1 Martin, Vicente
A1 Dierssen-Sotos, Trinidad
A1 Jimenez-Moleon, Jose J.
A1 Castilla, Jesus
A1 Tardon, Adonina
A1 Ruiz, Irune
A1 Peiro, Rosana
A1 Tejada, Antonio
A1 Chirlaque, Maria D.
A1 Butt, Julia A.
A1 Olmedo-Requena, Rocio
A1 Gomez-Acebo, Ines
A1 Linares, Pedro
A1 Boldo, Elena
A1 Castells, Antoni
A1 Pawlita, Michael
A1 Castano-Vinyals, Gemma
A1 Kogevinas, Manolis
A1 de Sanjose, Silvia
A1 Pollan, Marina
A1 del Campo, Rosa
A1 Waterboer, Tim
A1 Aragones, Nuria
K1 Helicobacter pylori
K1 multiplex serology
K1 colorectal neoplasm
K1 chronic infection
K1 bacterial infections
K1 non-infectious diseases
K1 Gastric-cancer
K1 Colon neoplasia
K1 Infection
K1 Association
K1 Metaanalysis
K1 Carcinoma
AB Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain.Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >= 4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag delta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women.Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.
PB Frontiers media sa
YR 2017
FD 2017-05-29
LK http://hdl.handle.net/10668/19223
UL http://hdl.handle.net/10668/19223
LA en
DS RISalud
RD Apr 9, 2025