RT Journal Article
T1 Role of the Gut Microbiome in Beta Cell and Adipose Tissue Crosstalk: A Review.
A1 Martínez-Montoro, José Ignacio
A1 Damas-Fuentes, Miguel
A1 Fernández-García, José Carlos
A1 Tinahones, Francisco J
K1 adipokines
K1 adipose tissue
K1 beta cell
K1 diabetes
K1 gut microbiota
K1 inflammation
K1 insulin resistance
AB In the last decades, obesity has reached epidemic proportions worldwide. Obesity is a chronic disease associated with a wide range of comorbidities, including insulin resistance and type 2 diabetes mellitus (T2D), which results in significant burden of disease and major consequences on health care systems. Of note, intricate interactions, including different signaling pathways, are necessary for the establishment and progression of these two closely related conditions. Altered cell-to-cell communication among the different players implicated in this equation leads to the perpetuation of a vicious circle associated with an increased risk for the development of obesity-related complications, such as T2D, which in turn contributes to the development of cardiovascular disease. In this regard, the dialogue between the adipocyte and pancreatic beta cells has been extensively studied, although some connections are yet to be fully elucidated. In this review, we explore the potential pathological mechanisms linking adipocyte dysfunction and pancreatic beta cell impairment/insulin resistance. In addition, we evaluate the role of emerging actors, such as the gut microbiome, in this complex crosstalk.
SN 1664-2392
YR 2022
FD 2022-05-12
LK http://hdl.handle.net/10668/20565
UL http://hdl.handle.net/10668/20565
LA en
DS RISalud
RD Apr 7, 2025