%0 Journal Article
%A Doña, Inmaculada
%A Torres, Maria Jose
%T A new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema.
%D 2021
%U http://hdl.handle.net/10668/17250
%X Hereditary angioedema (HAE) is a rare inherited chronic disease characterized by unpredictable recurrent attacks of cutaneous and submucosal swelling potentially involving airways, frequently upper ones, and compromising patient's life. This implies a serious health problem with significant disease burden and reduced life quality. This disease presents a great clinical variability and different endotypes, hampering diagnosis and requiring a personalized treatment. The primary mediator of swelling in most phenotypes is bradykinin, which increases vasodilation and vascular permeability by binding to the bradykinin B2 receptor.
%K Vasodilation
%K Chronic Disease
%K Angioedemas, Hereditary
%K Quality of Life
%K Bradykinin
%K Cost of Illness
%K Capillary Permeability
%K Andalusian Center for Nanomedicine and Biotechnology-BIONAND
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