RT Journal Article
T1 An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study.
A1 Vals-Delgado, Cristina
A1 Alcala-Diaz, Juan F
A1 Molina-Abril, Helena
A1 Roncero-Ramos, Irene
A1 Caspers, Martien P M
A1 Schuren, Frank H J
A1 Van den Broek, Tim J
A1 Luque, Raul
A1 Perez-Martinez, Pablo
A1 Katsiki, Niki
A1 Delgado-Lista, Javier
A1 Ordovas, Jose M
A1 van Ommen, Ben
A1 Camargo, Antonio
A1 Lopez-Miranda, Jose
K1 CORDIOPREV
K1 Coronary heart disease
K1 Intestinal microbiota
K1 Predictive model
K1 Type 2 diabetes mellitus
AB A distinctive gut microbiome have been linked to type 2 diabetes mellitus (T2DM). We aimed to evaluate whether gut microbiota composition, in addition to clinical biomarkers, could improve the prediction of new incident cases of diabetes in patients with coronary heart disease. All the patients from the CORDIOPREV (Clinical Trials.gov.Identifier: NCT00924937) study without T2DM at baseline were included (n = 462). Overall, 107 patients developed it after a median of 60 months. The gut microbiota composition was determined by 16S rRNA gene sequencing and predictive models were created using hold-out method. A gut microbiota profile associated with T2DM development was determined through a microbiome-based predictive model. The addition of microbiome data to clinical parameters (variables included in FINDRISC risk score and the diabetes risk score of the American Diabetes Association, HDL, triglycerides and HbA1c) improved the prediction increasing the area under the curve from 0.632 to 0.946. Furthermore, a microbiome-based risk score including the ten most discriminant genera, was associated with the probability of develop T2DM. These results suggest that a microbiota profile is associated to the T2DM development. An integrate predictive model of microbiome and clinical data that can improve the prediction of T2DM is also proposed, if is validated in independent populations to prevent this disease.
PB Elsevier
YR 2021
FD 2021-05-09
LK http://hdl.handle.net/10668/22290
UL http://hdl.handle.net/10668/22290
LA en
NO Vals-Delgado C, Alcala-Diaz JF, Molina-Abril H, Roncero-Ramos I, Caspers MPM, Schuren FHJ, et al. An altered microbiota pattern precedes Type 2 diabetes mellitus development: From the CORDIOPREV study. J Adv Res. 2021 May 13;35:99-108
NO The CIBEROBN is an initiative of the Instituto de Salud Carlos III, Madrid, Spain. We want to acknowledge the Biobank of the Sistema Sanitario Público de Andalucía (Andalusia, Spain) (Córdoba branch), for the human biological samples provided. We also thank the performed the randomization process by the EASP (Escuela Andaluza de Salud Publica), Granada, Spain. The CORDIOPREV study is supported by Ministerio de Economía y Competitividad (PIE14/00005, 14/00031, and AGL2012/39615, to J. L.-M.;AGL2015-67896-P to J.L.-M. and A.C.; FIS PI13/00023 to J.D.-L., PI16/01777 to P.P.-M. FIS PI19/00299 to A.C.; DTS19/00007 to A. C., CP14/00114 to A.C.); Fundación Patrimonio Comunal Olivarero, Diputaciones de Jaén y Córdoba, Junta de Andalucía (Consejería de Salud, Consejeria de Innovación, Ciencia y Empresa Consejería de Agricultura y Pesca,), Ministerio de Medio Ambiente, Medio Rural y Marino, Gobierno de España; Consejeria de Innovación, Ciencia y Empresa, and Centro de Excelencia en Investigación sobre Aceite de Oliva y Salud, , Junta de Andalucía (Proyectos de Investigación de Excelencia CVI-7450 to J.L.-M.); J.M.O. is supported by the US Department of Agriculture, under agreement no. 8050-51000-098-00D. We also thank the European Reginal Development Fond. We also thank Jose Andrés Morales Martínez for his technical support.
DS RISalud
RD Apr 17, 2025