RT Journal Article
T1 Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia.
A1 Montull, Beatriz
A1 Menéndez, Rosario
A1 Torres, Antoni
A1 Reyes, Soledad
A1 Méndez, Raúl
A1 Zalacaín, Rafael
A1 Capelastegui, Alberto
A1 Rajas, Olga
A1 Borderías, Luis
A1 Martin-Villasclaras, Juan
A1 Bello, Salvador
A1 Alfageme, Inmaculada
A1 Rodríguez de Castro, Felipe
A1 Rello, Jordi
A1 Molinos, Luis
A1 Ruiz-Manzano, Juan
K1 Infecciones adquiridas en la comunidad
K1 Anciano
K1 Femenino
K1 Humanos
K1 Duración de estancia hospitalaria
K1 Masculino
K1 Mediana edad
K1 Neumonía bacteriana
K1 Neumonía vírica
K1 Estudios prospectivos
K1 Factores de riesgo
K1 Sepsis
K1 Índice de la gravedad de la enfermedad
AB BACKGROUNDSevere sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP).OBJECTIVETo determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP.RESULTSWe performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospitalized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07-1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50-2.04) and renal disease (OR, 1.57; 95% CI, 1.21-2.03), whereas prior antibiotic treatment was a protective factor (OR, 0.62; 95% CI, 0.52-0.73). Bacteremia (OR, 1.37; 95% CI, 1.05-1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31-1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10-2.49) were associated with severe sepsis CAP.CONCLUSIONSCAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
PB Public Libray of Science
YR 2016
FD 2016-01-04
LK http://hdl.handle.net/10668/2394
UL http://hdl.handle.net/10668/2394
LA en
NO Montull B, Menéndez R, Torres A, Reyes S, Méndez R, Zalacaín R, et al. Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia. PLoS ONE. 2016; 11(1):e0145929
NO Journal Article; Multicenter Study; Observational Study;
DS RISalud
RD Jul 31, 2025