%0 Journal Article
%A Montull, Beatriz
%A Menéndez, Rosario
%A Torres, Antoni
%A Reyes, Soledad
%A Méndez, Raúl
%A Zalacaín, Rafael
%A Capelastegui, Alberto
%A Rajas, Olga
%A Borderías, Luis
%A Martin-Villasclaras, Juan
%A Bello, Salvador
%A Alfageme, Inmaculada
%A Rodríguez de Castro, Felipe
%A Rello, Jordi
%A Molinos, Luis
%A Ruiz-Manzano, Juan
%T Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia.
%D 2016
%U http://hdl.handle.net/10668/2394
%X BACKGROUNDSevere sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP).OBJECTIVETo determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP.RESULTSWe performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospitalized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07-1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50-2.04) and renal disease (OR, 1.57; 95% CI, 1.21-2.03), whereas prior antibiotic treatment was a protective factor (OR, 0.62; 95% CI, 0.52-0.73). Bacteremia (OR, 1.37; 95% CI, 1.05-1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31-1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10-2.49) were associated with severe sepsis CAP.CONCLUSIONSCAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
%K Infecciones adquiridas en la comunidad
%K Anciano
%K Femenino
%K Humanos
%K Duración de estancia hospitalaria
%K Masculino
%K Mediana edad
%K Neumonía bacteriana
%K Neumonía vírica
%K Estudios prospectivos
%K Factores de riesgo
%K Sepsis
%K Índice de la gravedad de la enfermedad
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