RT Journal Article
T1 Cognitive reserve, neurocognitive performance, and high-order resting-state networks in cognitively unimpaired aging.
A1 Varela-Lopez, Benxamin
A1 Cruz-Gomez, Alvaro Javier
A1 Lojo-Seoane, Cristina
A1 Diaz, Fernando
A1 Pereiro, A X
A1 Zurron, Montserrat
A1 Lindín, Monica
A1 Galdo-Alvarez, Santiago
K1 Cognitive reserve
K1 DAN
K1 FPCN
K1 Healthy aging
K1 Resting-state functional magnetic resonance
AB Cognitive Reserve (CR) is considered a protective factor during the aging process. However, although CR is a multifactorial construct, it has been operationalized in a unitary way (years of formal education or IQ). In the present study, a validated measure to categorize CR holistically (Cognitive Reserve Index Questionnaire) was used to evaluate the resting-state functional connectivity in 77 cognitively unimpaired participants aged 50 years and over with high and low CR, and matched brain global atrophy levels. The connectivity of networks linked to attentional (Dorsal Attention Network -DAN-) and executive (Frontal-Parietal Control Network -FPCN-) processes were evaluated by the combination of Independent Component Analysis and seed-based approaches, since these networks have been proposed as candidates to underlie the protective effect of CR in the aging context. Participants with high CR showed an increase of the connectivity in the FPCN and a decrease in the DAN with respect to the low CR group, correlating with neuropsychological scores and supporting that high CR is related to a better neurocognitive preservation during aging.
PB Elsevier
YR 2022
FD 2022-05-07
LK http://hdl.handle.net/10668/22422
UL http://hdl.handle.net/10668/22422
LA en
NO Varela-López B, Cruz-Gómez ÁJ, Lojo-Seoane C, Díaz F, Pereiro AX, Zurrón M, et al. Cognitive reserve, neurocognitive performance, and high-order resting-state networks in cognitively unimpaired aging. Neurobiol Aging. 2022 Sep;117:151-164
NO This study was supported by grants from the Spanish Government, Ministerio de Ciencia e Innovación (PSI2017-89389-C2-R; PID2020-114521RB-C21/C22); the Galician Government (Xunta de Galicia), Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807-USC); Ref: ED431-2017/27; ED431C-2021/04; all with ERDF/FEDER funds.
DS RISalud
RD Apr 5, 2025