RT Journal Article
T1 Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).
A1 Mahamat-Saleh, Yahya
A1 Al-Rahmoun, Marie
A1 Severi, Gianluca
A1 Ghiasvand, Reza
A1 Veierod, Marit B
A1 Caini, Saverio
A1 Palli, Domenico
A1 Botteri, Edoardo
A1 Sacerdote, Carlotta
A1 Ricceri, Fulvio
A1 Lukic, Marko
A1 Sanchez-Perez, Maria-Jose
A1 Pala, Valeria
A1 Tumino, Rosario
A1 Chiodini, Paolo
A1 Amiano, Pilar
A1 Colorado-Yohar, Sandra
A1 Chirlaque, María-Dolores
A1 Ardanaz, Eva
A1 Bonet, Catalina
A1 Katzke, Verena
A1 Kaaks, Rudolf
A1 Schulze, Matthias B
A1 Overvad, Kim
A1 Dahm, Christina C
A1 Antoniussen, Christian S
A1 Tjønneland, Anne
A1 Kyrø, Cecilie
A1 Bueno-de-Mesquita, Bas
A1 Manjer, Jonas
A1 Jansson, Malin
A1 Esberg, Anders
A1 Mori, Nagisa
A1 Ferrari, Pietro
A1 Weiderpass, Elisabete
A1 Boutron-Ruault, Marie-Christine
A1 Kvaskoff, Marina
K1 alcohol
K1 cohort studies
K1 cutaneous melanoma
K1 epidemiology
K1 keratinocyte cancers
AB Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal-cell carcinoma (BCC): n = 8711; squamous-cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow-up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1-4.9 g/day: HR = 1.44, 95% CI = 1.17-1.77; Ptrend  = .001), BCC (HR = 1.12, 95% CI = 1.01-1.23; Ptrend  = .04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95-1.44; Ptrend  = .17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90-1.30; Ptrend  = .13; BCC: HR = 1.08, 95% CI = 1.00-1.17, Ptrend  = .03; melanoma: HR = 0.93, 95% CI = 0.80-1.08, Ptrend  = .13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08-1.99; Ptrend  = .0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04-1.31; Ptrend  = .14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11-1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer.
PB John Wiley & Sons, Inc.
YR 2022
FD 2022-07-05
LK http://hdl.handle.net/10668/22095
UL http://hdl.handle.net/10668/22095
LA en
NO Mahamat-Saleh Y, Al-Rahmoun M, Severi G, Ghiasvand R, Veierod MB, Caini S, et al. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Int J Cancer. 2023 Feb 1;152(3):348-362.
NO Yahya Mahamat-Saleh was supported by the French National Cancer Institute (INCa). The coordination of EPIC is financially supported by the European Commission (DG-SANCO); and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); the French National Institute of Health and Medical Research (Inserm), the Mutuelle Générale de l'Education Nationale, the Gustave Roussy Institute, and the French League against Cancer (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ); and Federal Ministry of Education and Research (Germany); Stavros Niarchos Foundation; the Hellenic Health Foundation; and Ministry of Health and Social Solidarity (Greece); Italian Association for Research on Cancer (AIRC); National Research Council; and AIRE-ONLUS Ragusa, AVIS Ragusa, Sicilian Government (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research Funds; Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); the National Institute for Public Health and the Environment (RIVM) and Statistics Netherlands (the Netherlands); European Research Council (ERC) (grant number ERC-2009-AdG 232997) and Nordforsk; and Nordic Center of Excellence Programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS); Regional Governments of Andalucía, Asturias, Basque Country, Murcia (No. 6236) and Navarra; and ISCIII RETIC (RD06/0020) and the Catalan Institute of Oncology. (Spain); Swedish Cancer Society; Swedish Scientific Council; and Regional Government of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 for EPIC-Oxford); Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford); Stroke Association; British Heart Foundation; Department of Health; Food Standards Agency; and Wellcome Trust (UK).
DS RISalud
RD Apr 5, 2025