RT Journal Article
T1 Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists.
A1 Tejada, Miguel A
A1 Montilla-Garcia, Angeles
A1 Gonzalez-Cano, Rafael
A1 Bravo-Caparros, Inmaculada
A1 Ruiz-Cantero, M Carmen
A1 Nieto, Francisco R
A1 Cobos, Enrique J
K1 Analgesia
K1 Endogenous opioid peptides
K1 Immune cells
K1 Neuro-immune interactions
K1 Sigma-1 receptors
AB Immune cells have a known role in pronociception, since they release a myriad of inflammatory algogens which interact with neurons to facilitate pain signaling. However, these cells also produce endogenous opioid peptides with analgesic potential. The sigma-1 receptor is a ligand-operated chaperone that modulates neurotransmission by interacting with multiple protein partners, including the μ-opioid receptor. We recently found that sigma-1 antagonists are able to induce opioid analgesia by enhancing the action of endogenous opioid peptides of immune origin during inflammation. This opioid analgesia is seen only at the inflamed site, where immune cells naturally accumulate. In this article we review the difficulties of targeting the opioid system for selective pain relief, and discuss the dual role of immune cells in pain and analgesia. Our discussion creates perspectives for possible novel therapeutic uses of sigma-1 antagonists as agents able to maximize the analgesic potential of the immune system.
PB Elsevier Ltd
YR 2018
FD 2018-02-15
LK http://hdl.handle.net/10668/12150
UL http://hdl.handle.net/10668/12150
LA en
NO Tejada MÁ, Montilla-García Á, González-Cano R, Bravo-Caparrós I, Ruiz-Cantero MC, Nieto FR, et al. argeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists. Pharmacol Res. 2018 May;131:224-230.
NO M.A. Tejada was supported by a pre-doctoral grant from the University of Granada. R. González-Cano was supported by a Martín Escudero postdoctoral fellowship. I. BravoCaparrós and M.C. Ruiz-Cantero were supported by FPU grants from the Spanish Ministry of Economy and Competitiveness (MINECO). F.R. Nieto was supported by a Juan de la Cierva postdoctoral grant from MINECO. This study was partially supported by MINECO [grant number SAF2016- 80540-R], the Junta de Andalucía (grant CTS109) and FEDER fufunds. The authors thank K. Shashok for improving the use of English in the manuscript
DS RISalud
RD Apr 9, 2025