RT Journal Article
T1 C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19.
A1 Giner-Galvañ, Vicente
A1 Pomares-Gomez, Francisco Jose
A1 Quesada, Jose Antonio
A1 Rubio-Rivas, Manuel
A1 Tejada-Montes, Javier
A1 Baltasar-Corral, Jesus
A1 Taboada-Martinez, Maria Luisa
A1 Sanchez-Mesa, Blanca
A1 Arnalich-Fernandez, Francisco
A1 Del-Corral-Beamonte, Esther
A1 Lopez-Sampalo, Almudena
A1 Pesqueira-Fontan, Paula Maria
A1 Fernandez-Garces, Mar
A1 Gomez-Huelgas, Ricardo
A1 Ramos-Rincon, Jose Manuel
K1 C-reactive protein
K1 COVID-19
K1 Comorbidity
K1 Prognosis
K1 Serum albumin
K1 Syndemic
AB Background: C-reactive protein (CRP) and albumin are inflammatory markers. We analyzed the prognostic capacity of serum albumin (SA) and CRP for an outcome comprising mortality, length of stay, ICU admission, and non-invasive mechanical ventilation in hospitalized COVID-19 patients. (2) Methods: We conducted a retrospective cohort study based on the Spanish national SEMI-COVID-19 Registry. Two multivariate logistic models were adjusted for SA, CRP, and their combination. Training and testing samples were used to validate the models. (3) Results: The outcome was present in 41.1% of the 3471 participants, who had lower SA (mean [SD], 3.5 [0.6] g/dL vs. 3.8 [0.5] g/dL; p< 0.001) and higher CRP (108.9 [96.5] mg/L vs. 70.6 [70.3] mg/L; p < 0.001). In the adjusted multivariate model, both were associated with poorer evolution: SA, OR 0.674 (95% CI, 0.551–0.826; p < 0.001); CRP, OR 1.002 (95% CI, 1.001–1.004; p = 0.003). The CRP/SA model had a similar predictive capacity (honest AUC, 0.8135 [0.7865–0.8405]), with a continuously increasing risk and cutoff value of 25 showing the highest predictive capacity (OR, 1.470; 95% CI, 1.188–1.819; p <0.001). (4) Conclusions: SA and CRP are good independent predictors of patients hospitalized with COVID-19. For the CRP/SA ratio value, 25 is the cutoff for poor clinical course.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-06-13
LK http://hdl.handle.net/10668/20835
UL http://hdl.handle.net/10668/20835
LA en
NO Giner-Galvañ V, Pomares-Gómez FJ, Quesada JA, Rubio-Rivas M, Tejada-Montes J, Baltasar-Corral J, et al. C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19. Biomedicines. 2022 Jun 13;10(6):1393
DS RISalud
RD Apr 19, 2025