RT Journal Article
T1 In vivo antitumor activity of Euphorbia lathyris ethanol extract in colon cancer models.
A1 Mesas, C
A1 Martínez, R
A1 Doello, K
A1 Ortiz, R
A1 López-Jurado, M
A1 Bermúdez, Francisco
A1 Quiñonero, F
A1 Prados, J
A1 Porres, J M
A1 Melguizo, C
K1 AOM/DSS model
K1 Colon cancer
K1 Euphorbia lathyris
K1 Microbiome
K1 Orthotopic xenograft model
K1 Oxidative stress detoxification enzymes
AB Euphorbia lathyris seeds have been used to treat various medical conditions. We previously reported that ethanolic extract from the defatted seed of Euphorbia lathyris (EE) (variety S3201) possesses a potent in vitro antitumor activity against colon cancer (CRC) cell lines. However, the effects of EE on CRC in vivo models and its possible preventive activity have not been elucidated. The aim of this study is to develop an in vivo study to corroborate its efficacy. For this purpose, two tumor induction models have been developed. In orthotopic xenograft model, it has been shown that EE reduces tumor size without hematological toxicity. The ethanolic extract induced an intense apoptosis in tumors mediated by caspase 3. Using the Azoxymethane/Dextran Sulfate Sodium model, a reduction of dysplastic polyps has been demonstrated, showing its preventive power. Furthermore, EE promoted the presence of an eubiotic microbiotal environment in the mucosa of the colon and induced an increase in antioxidant enzyme activity. This fact was accompanied by a modulation of cytokine expression that could be related to its protective mechanism. Therefore, although further experiments will be necessary to determine its applicability in the treatment of CRC, ES could be a new prevention strategy as well as treatment for this type of tumor, being a powerful candidate for future clinical trials.
PB Elsevier Masson
YR 2022
FD 2022-03-23
LK http://hdl.handle.net/10668/22042
UL http://hdl.handle.net/10668/22042
LA en
NO Mesas C, Martínez R, Doello K, Ortiz R, López-Jurado M, Bermúdez F, et al. In vivo antitumor activity of Euphorbia lathyris ethanol extract in colon cancer models. Biomed Pharmacother. 2022 May;149:12.
NO This research was funded by the Spanish Ministry of Science, Innovation, and Universities through projects RTC-2017-6540-1 , RTC2019-006870-1 , Junta de Andalucía through project P18-TP-1420 and FEDER Program . In addition, this work was supported by funds from research groups AGR145 and CTS-107 ( Andalusian Government ).
DS RISalud
RD Apr 5, 2025