RT Journal Article
T1 Does corticosteroid treatment during the pre and postnatal periods affect the neurodevelopmental outcome of premature newborns?
A1 Lardon, Marita
A1 Uberos, Jose
A1 Narbona, Eduardo
K1 Adrenal cortex hormones
K1 dexamethasone
K1 betamethasone
K1 therapeutics
K1 premature birth
K1 neurodevelopmental disorders
K1 Low-birth-weight
K1 Chronic lung-disease
K1 Preterm infants
K1 Bronchopulmonary dysplasia
K1 Antenatal corticosteroids
K1 Dexamethasone
K1 Risk
K1 Steroids
K1 Exposure
K1 Trial
AB Introduction: Glucocorticoids, widely used in the perinatal period, may be associated with adverse neurodevelopmental effects.Objectives: To analyze neurodevelopmental outcomes in a cohort of very low birth weight newborns treated with antenatal and/or postnatal corticosteroids.Materials and methods: This was a prospective cohort study in which we included all very low birth weight babies admitted to the neonatal intensive care unit of a tertiary hospital between 2008 and 2013. We compared the neurodevelopment among very low birth-weight newborns who did not receive prenatal corticosteroid therapy and those who received a complete course (two doses of 12 mg betamethasone) and an incomplete course (one dose), and between those who did not receive postnatal corticosteroid therapy and those who received it (systemic dexamethasone after the first week of life). Motor, neurosensory and cognitive functions, as well as behavior disorders during the first two years of age were evaluated.Results: A total of 225 very low birth weight newborns were analyzed; 83.6% received prenatal corticosteroid therapy (24% incomplete treatment schedule and 59.6% complete schedule). Only 13.3% received systemic dexamethasone during the postnatal period. Neurological monitoring was performed in 194 infants. Logistic regression analysis did not detect an association between prenatal and postnatal corticosteroid therapy and more neurological disorders, and no significant differences were found among those who received complete and incomplete courses of prenatal corticosteroid therapy.Conclusion: These results did not demonstrate an association between perinatal corticosteroid therapy and worse neurodevelopmental outcomes in very low birth weight newborns.
PB Inst nacional salud
SN 0120-4157
YR 2017
FD 2017-04-01
LK http://hdl.handle.net/10668/19397
UL http://hdl.handle.net/10668/19397
LA es
DS RISalud
RD Apr 11, 2025