RT Journal Article
T1 Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering.
A1 Rico-Llanos, Gustavo A
A1 Borrego-González, Sara
A1 Moncayo-Donoso, Miguelangel
A1 Becerra, José
A1 Visser, Rick
K1 bone tissue engineering
K1 collagen
K1 growth factors
K1 peptides
K1 scaffolds
AB Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration.
YR 2021
FD 2021-02-17
LK https://hdl.handle.net/10668/24780
UL https://hdl.handle.net/10668/24780
LA en
DS RISalud
RD Apr 17, 2025