%0 Journal Article
%A Duque-Sosa, Paula
%A Martínez-Urbistondo, Diego
%A Echarri, Gemma
%A Callejas, Raquel
%A Iribarren, María Josefa
%A Rábago, Gregorio
%A Monedero, Pablo
%A Spanish group of renal dysfunction in cardiac surgery (GEDRCC-2)
%T Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study.
%D 2017
%U https://hdl.handle.net/10668/25301
%X Perioperative anemia is an important risk factor for cardiac surgery-associated acute kidney injury (CSA-AKI). Nonetheless, the severity of the anemia and the time in the perioperative period in which the hemoglobin level should be considered as a risk factor is conflicting. The present study introduces the concept of perioperative hemoglobin area under the curve (pHb-AUC) as a surrogate marker of the evolution of perioperative hemoglobin concentration. Through a retrospective analysis of prospectively collected data, we assessed this new variable as a risk factor for the development of acute kidney injury after cardiac surgery in 966 adult patients who underwent cardiac surgery with cardiopulmonary bypass, at twenty-three academic hospitals in Spain. Exclusion criteria were patients on renal replacement therapy, who needed a reoperation because of bleeding and/or with missing perioperative hemoglobin or creatinine values. Using a multivariate regression analysis, we found that a pHb-AUC
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