RT Journal Article
T1 Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis.
A1 Birks, Laura
A1 Casas, Maribel
A1 Garcia, Ana M
A1 Alexander, Jan
A1 Barros, Henrique
A1 Bergström, Anna
A1 Bonde, Jens Peter
A1 Burdorf, Alex
A1 Costet, Nathalie
A1 Danileviciute, Asta
A1 Eggesbø, Merete
A1 Fernández, Mariana F
A1 González-Galarzo, M Carmen
A1 Regina Gražulevičienė, 
A1 Hanke, Wojciech
A1 Jaddoe, Vincent
A1 Kogevinas, Manolis
A1 Kull, Inger
A1 Lertxundi, Aitana
A1 Melaki, Vasiliki
A1 Andersen, Anne-Marie Nybo
A1 Olea, Nicolás
A1 Polanska, Kinga
A1 Rusconi, Franca
A1 Santa-Marina, Loreto
A1 Santos, Ana Cristina
A1 Vrijkotte, Tanja
A1 Zugna, Daniela
A1 Nieuwenhuijsen, Mark
A1 Cordier, Sylvaine
A1 Vrijheid, Martine
K1 Birth Weight
K1 Endocrine Disruptors
K1 Europe
K1 Female
K1 Gestational Age
AB Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p  Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW. Citation: Birks L, Casas M, Garcia AM, Alexander J, Barros H, Bergström A, Bonde JP, Burdorf A, Costet N, Danileviciute A, Eggesbø M, Fernández MF, González-Galarzo MC, Gražulevičienė R, Hanke W, Jaddoe V, Kogevinas M, Kull I, Lertxundi A, Melaki V, Andersen AM, Olea N, Polanska K, Rusconi F, Santa-Marina L, Santos AC, Vrijkotte T, Zugna D, Nieuwenhuijsen M, Cordier S, Vrijheid M. 2016. Occupational exposure to endocrine-disrupting chemicals and birth weight and length of gestation: a European meta-analysis. Environ Health Perspect 124:1785-1793; http://dx.doi.org/10.1289/EHP208.
PB U.S. Department of Health and Human Services * National Institute of Environmental Health Sciences
YR 2016
FD 2016-04-28
LK http://hdl.handle.net/10668/10060
UL http://hdl.handle.net/10668/10060
LA en
NO Birks L, Casas M, Garcia AM, Alexander J, Barros H, Bergström A, et al. Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis. Environ Health Perspect. 2016 Nov;124(11):1785-1793.
DS RISalud
RD Apr 8, 2025