RT Journal Article
T1 The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study.
A1 Pires, Liliane Viana
A1 González-Gil, Esther M
A1 Anguita-Ruiz, Augusto
A1 Bueno, Gloria
A1 Gil-Campos, Mercedes
A1 Vázquez-Cobela, Rocío
A1 Pérez-Ferreirós, Alexandra
A1 Moreno, Luis A
A1 Gil, Ángel
A1 Leis, Rosaura
A1 Aguilera, Concepción M
K1 cardiometabolic risk factors
K1 child
K1 insulin resistance
K1 obesity
K1 puberty
K1 vitamin D
AB Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4-12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = -0.274, p = 0.032; B = -0.219, p = 0.019; B = -0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p
YR 2021
FD 2021-12-15
LK https://hdl.handle.net/10668/25671
UL https://hdl.handle.net/10668/25671
LA en
DS RISalud
RD Apr 17, 2025