RT Journal Article
T1 Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption.
A1 González, Ana
A1 Gálvez, Natividad
A1 Martín, Jesús
A1 Reyes, Fernando
A1 Pérez-Victoria, Ignacio
A1 Dominguez-Vera, Jose M
K1 Iron metabolism
K1 Iron supplement
K1 Lactobacillus fermentum
K1 Probiotic bacteria
AB We have taken a vital step towards understanding why probiotic bacteria increase iron absorption in the gastrointestinal tract. We show here that Lactobacillus fermentum, one of the main probiotics of the microbiota, exhibits an extraordinary ferric-reducing activity. This activity is predominantly due to an excreted molecule: p-hydroxyphenyllactic acid (HPLA). Reduction of Fe(III) to Fe(II) is essential for iron absorption in the gastrointestinal tract. By reducing Fe(III), HPLA boosts Fe(II) absorption through the DMT1 channels of enterocytes. An in vitro experiment tested and confirmed this hypothesis. This discovery opens new avenues for the treatment of iron deficiency in humans, one of the most common and widespread nutritional disorders in the world.
YR 2017
FD 2017-02-04
LK http://hdl.handle.net/10668/10973
UL http://hdl.handle.net/10668/10973
LA en
DS RISalud
RD Apr 7, 2025