RT Journal Article
T1 Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr-/-.Leiden mice without attenuation of steatohepatitis
A1 Álvarez-Amor, Leticia
A1 Sierra, Amparo Luque
A1 Cárdenas, Antonio
A1 López-Bermudo, Lucía
A1 López-Beas, Javier
A1 Andújar, Eloísa
A1 Pérez-Alegre, Mónica
A1 Gallego-Durán, Rocío
A1 Varela, Lourdes M.
A1 Martin-Montalvo, Alejandro
A1 Berná, Genoveva
A1 Rojas, Anabel
A1 Robles-Frías, Mª José
A1 Hmadcha, Abdelkrim
A1 Romero-Gómez, Manuel
A1 Kleemann, Robert
A1 Martín, Franz
K1 Extra virgin olive oil
K1 Insulin sensitivity
K1 Body weight
K1 steatohepatitis
K1 LDL
K1 Diet, high-fat
K1 Aceite de oliva
K1 Resistencia a la insulina
K1 Peso corporal
K1 Hígado graso
K1 Lipoproteínas LDL
K1 Dieta alta en grasa
AB Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition is critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) is the main source of monounsaturated fatty acids (MUFA) in Mediterranean diets. This study examined whether EVOO-containing high fat diets may prevent diet-induced NAFLD using Ldlr-/-. Leiden mice. In female Ldlr-/-.Leiden mice, the effects of the following high fat diets (HFDs) were examined: a lard-based HFD (HFD-L); an EVOO-based HFD (HFD-EVOO); a phenolic compounds-rich EVOO HFD (HFD-OL). We studied changes in body weight (BW), lipid profile, transaminases, glucose homeostasis, liver pathology and transcriptome. Both EVOO diets reduced body weight (BW) and improved insulin sensitivity. The EVOOs did not improve transaminase values and increased LDL-cholesterol and liver collagen content. EVOOs and HFD-L groups had comparable liver steatosis. The profibrotic effects were substantiated by an up-regulation of gene transcripts related to glutathione metabolism, chemokine signaling and NF-kappa-B activation and down-regulation of genes relevant for fatty acid metabolism. Collectivelly, EVOO intake improved weight gain and insulin sensitivity but not liver inflammation and fibrosis, which was supported by changes in hepatic genes expression.
PB Springer Nature
YR 2021
FD 2021-04-15
LK http://hdl.handle.net/10668/4006
UL http://hdl.handle.net/10668/4006
LA en
NO Álvarez-Amor L, Sierra AL, Cárdenas A, López-Bermudo L, López-Beas J, Andújar E, et al. Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr-/-.Leiden mice without attenuation of steatohepatitis. Sci Rep. 2021 Apr 15;11(1):8250
DS RISalud
RD Apr 10, 2025