RT Journal Article
T1 Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.
A1 Marini, Sandro
A1 Crawford, Katherine
A1 Morotti, Andrea
A1 Lee, Myung J
A1 Pezzini, Alessandro
A1 Moomaw, Charles J
A1 Flaherty, Matthew L
A1 Montaner, Joan
A1 Roquer, Jaume
A1 Jimenez-Conde, Jordi
A1 Giralt-Steinhauer, Eva
A1 Elosua, Roberto
A1 Cuadrado-Godia, Elisa
A1 Soriano-Tarraga, Carolina
A1 Slowik, Agnieszka
A1 Jagiella, Jeremiasz M
A1 Pera, Joanna
A1 Urbanik, Andrzej
A1 Pichler, Alexander
A1 Hansen, Björn M
A1 McCauley, Jacob L
A1 Tirschwell, David L
A1 Selim, Magdy
A1 Brown, Devin L
A1 Silliman, Scott L
A1 Worrall, Bradford B
A1 Meschia, James F
A1 Kidwell, Chelsea S
A1 Testai, Fernando D
A1 Kittner, Steven J
A1 Schmidt, Helena
A1 Enzinger, Christian
A1 Deary, Ian J
A1 Rannikmae, Kristiina
A1 Samarasekera, Neshika
A1 Al-Shahi Salman, Rustam
A1 Sudlow, Catherine L
A1 Klijn, Catharina J M
A1 van Nieuwenhuizen, Koen M
A1 Fernandez-Cadenas, Israel
A1 Delgado, Pilar
A1 Norrving, Bo
A1 Lindgren, Arne
A1 Goldstein, Joshua N
A1 Viswanathan, Anand
A1 Greenberg, Steven M
A1 Falcone, Guido J
A1 Biffi, Alessandro
A1 Langefeld, Carl D
A1 Woo, Daniel
A1 Rosand, Jonathan
A1 Anderson, Christopher D
K1 Black or African American
K1 Aged, 80 and over
K1 Cerebral Hemorrhage
K1 Genetic Predisposition to Disease
K1 Hypertension
K1 Middle Aged
K1 White People
AB Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ε4 alleles, the most potent genetic risk factor for ICH. This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. In total, 13 124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE ε2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P  APOE ε4 and ε2 alleles appear to affect lobar ICH risk variably by race/ethnicity, associations that are confirmed in white individuals but can be shown in Hispanic individuals only when the excess burden of hypertension is propensity score-matched; further studies are needed to explore the interactions between APOE alleles and environmental exposures that vary by race/ethnicity in representative populations at risk for ICH.
YR 2019
FD 2019-02-06
LK http://hdl.handle.net/10668/13524
UL http://hdl.handle.net/10668/13524
LA en
NO Marini S, Crawford K, Morotti A, Lee MJ, Pezzini A, Moomaw CJ, et al. Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis. JAMA Neurol. 2019 Apr 1;76(4):480-491.
DS RISalud
RD Apr 20, 2025