RT Journal Article
T1 The RhoB small GTPase in physiology and disease.
A1 Vega, Francisco M
A1 Ridley, Anne J
K1 Rho GTPases
K1 RhoB
K1 cancer progression
K1 development
K1 membrane trafficking
AB RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.
YR 2016
FD 2016-11-22
LK https://hdl.handle.net/10668/25394
UL https://hdl.handle.net/10668/25394
LA en
DS RISalud
RD Apr 10, 2025