%0 Journal Article
%A Vega, Francisco M
%A Ridley, Anne J
%T The RhoB small GTPase in physiology and disease.
%D 2016
%U https://hdl.handle.net/10668/25394
%X RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.
%K Rho GTPases
%K RhoB
%K cancer progression
%K development
%K membrane trafficking
%~