RT Journal Article
T1 Natural Course of the Diffusing Capacity of the Lungs for Carbon Monoxide in COPD: Importance of Sex.
A1 Casanova, Ciro
A1 Gonzalez-Davila, Enrique
A1 Martinez-Gonzalez, Cristina
A1 Cosio, Borja G
A1 Fuster, Antonia
A1 Feu, Nuria
A1 Solanes, Ingrid
A1 Cabrera, Carlos
A1 Marin, Jose M
A1 Balcells, Eva
A1 Peces-Barba, German
A1 de Torres, Juan P
A1 Marin-Oto, Marta
A1 Calle, Myriam
A1 Golpe, Rafael
A1 Ojeda, Elena
A1 Divo, Miguel
A1 Pinto-Plata, Victor
A1 Amado, Carlos
A1 Lopez-Campos, Jose Luis
A1 Celli, Bartolome R
K1 COPD
K1 Diffusing capacity of the lungs for carbon monoxide
K1 Lung function decline
K1 Sex
AB The value of the single-breath diffusing capacity of the lungs for carbon monoxide (Dlco) relates to outcomes for patients with COPD. However, little is known about the natural course of Dlco over time, intersubject variability, and factors that may influence Dlco progression. What is the natural course of Dlco in patients with COPD over time, and which other factors, including sex differences, could influence this progression? We phenotyped 602 smokers (women, 33%), of whom 506 (84%) had COPD and 96 (16%) had no airflow limitation. Lung function, including Dlco, was monitored annually over 5 years. A random coefficients model was used to evaluate Dlco changes over time. The mean (± SE) yearly decline in Dlco % in patients with COPD was 1.34% ± 0.015%/y. This was steeper compared with non-COPD control subjects (0.04% ± 0.032%/y; P = .004). Sixteen percent of the patients with COPD, vs 4.3% of the control subjects, had a statistically significant Dlco % slope annual decline (4.14%/y). At baseline, women with COPD had lower Dlco values (11.37% ± 2.27%; P  Patients with COPD have an accelerated decline in Dlco compared with smokers without the disease. However, the decline is slow, and a testing interval of 3 to 4 years may be clinically informative. The lower and more rapid decline in Dlco values in women, compared with men, suggests a differential impact of sex in gas exchange function. 
PB Elsevier
YR 2021
FD 2021-04-18
LK http://hdl.handle.net/10668/17608
UL http://hdl.handle.net/10668/17608
LA en
NO Casanova C, Gonzalez-Dávila E, Martínez-Gonzalez C, Cosio BG, Fuster A, Feu N, et al.  Natural Course of the Diffusing Capacity of the Lungs for Carbon Monoxide in COPD: Importance of Sex. Chest. 2021 Aug;160(2):481-490
DS RISalud
RD Apr 9, 2025