RT Journal Article T1 Prognostic Implication of Non-Obstructive Coronary Lesions: A New Classification in Different Settings. A1 Rodríguez-Capitán, Jorge A1 Sánchez-Pérez, Andrés A1 Ballesteros-Pradas, Sara A1 Millán-Gómez, Mercedes A1 Cardenal-Piris, Rosa A1 Oneto-Fernández, Manuel A1 Gutiérrez-Alonso, Lola A1 Rivera-López, Ricardo A1 Guisado-Rasco, Agustín A1 Cano-García, Macarena A1 Gutiérrez-Bedmar, Mario A1 Jiménez-Navarro, Manuel K1 acute coronary syndrome K1 coronary angiography K1 coronary artery disease K1 diabetes mellitus K1 sex AB The clinical significance of non-obstructive coronary artery disease is the subject of debate. Our objective was to evaluate the long-term cardiovascular prognosis associated with non-obstructive coronary artery disease in patients undergoing coronary angiography, and to conduct a stratification by sex, diabetes, and clinical indication. We designed a multi-centre retrospective longitudinal observational study of 3265 patients that were classified into three groups: normal coronary arteries (lesion 70%, 1196 patients). During a mean follow-up of 43 months, we evaluated a combined cardiovascular event: acute myocardial infarction, stroke, hospitalization for heart failure, or cardiovascular death. Multivariable-adjusted Cox proportional hazard models showed a worse prognosis in patients with non-obstructive coronary artery disease, in comparison with patients of normal coronary arteries group, in the total population (hazard ratio 1.72, 95% confidence interval 1.23-2.39; p for trend SN 2077-0383 YR 2021 FD 2021-04-25 LK https://hdl.handle.net/10668/27187 UL https://hdl.handle.net/10668/27187 LA en DS RISalud RD Apr 8, 2025