RT Journal Article
T1 Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation-positive melanoma.
A1 Dréno, Brigitte
A1 Ascierto, Paolo A
A1 Atkinson, Victoria
A1 Liszkay, Gabriella
A1 Maio, Michele
A1 Mandalà, Mario
A1 Demidov, Lev
A1 Stroyakovskiy, Daniil
A1 Thomas, Luc
A1 de la Cruz-Merino, Luis
A1 Dutriaux, Caroline
A1 Garbe, Claus
A1 Bartley, Karen
A1 Karagiannis, Thomas
A1 Chang, Ilsung
A1 Rooney, Isabelle
A1 Koralek, Daniel O
A1 Larkin, James
A1 McArthur, Grant A
A1 Ribas, Antoni
AB In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. Patients completing the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (QLQ-C30) at baseline and ⩾1 time point thereafter constituted the analysis population. Change from baseline ⩾10 points was considered clinically meaningful. Mean baseline scores for all QLQ-C30 domains were similar between arms. Most on-treatment scores for QLQ-C30 domains were also comparable between arms. A transient deterioration in role function in cycle 1 day 15 (C1D15; -14.7 points) in the P+V arm and improvement in insomnia in the C+V arm at C2D15 (-12.4 points) was observed. Among patients who experienced a ⩾10-point change from baseline (responders), between-group differences were greatest for insomnia (16%), social functioning (10%), fatigue (9%) and pain (7%), all favouring C+V. Diarrhoea, photosensitivity reaction, pyrexia, and rash did not meaningfully affect global health status (GHS). Serous retinopathy was associated with a transient decrease in GHS at C1D15 assessment. In patients with advanced/metastatic BRAFV600-mutated melanoma, treatment with C+V maintained HRQOL compared with P+V, with superior efficacy.
YR 2018
FD 2018-02-13
LK http://hdl.handle.net/10668/12124
UL http://hdl.handle.net/10668/12124
LA en
DS RISalud
RD Apr 9, 2025