RT Journal Article
T1 Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
A1 Zamora-Ros, Raul
A1 Cayssials, Valerie
A1 Jenab, Mazda
A1 Rothwell, Joseph A
A1 Fedirko, Veronika
A1 Aleksandrova, Krasimira
A1 Tjønneland, Anne
A1 Kyrø, Cecilie
A1 Overvad, Kim
A1 Boutron-Ruault, Marie-Christine
A1 Carbonnel, Franck
A1 Mahamat-Saleh, Yahya
A1 Kaaks, Rudolf
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Valanou, Elissavet
A1 Vasilopoulou, Effie
A1 Masala, Giovanna
A1 Pala, Valeria
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Weiderpass, Elisabete
A1 Lukic, Marko
A1 Sandanger, Torkjel M
A1 Lasheras, Cristina
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Amiano, Pilar
A1 Navarro, Carmen
A1 Ardanaz, Eva
A1 Sonestedt, Emily
A1 Ohlsson, Bodil
A1 Nilsson, Lena Maria
A1 Rutegård, Martin
A1 Bueno-de-Mesquita, Bas
A1 Peeters, Petra H
A1 Khaw, Kay-Thee
A1 Wareham, Nicholas J
A1 Bradbury, Kathryn
A1 Freisling, Heinz
A1 Romieu, Isabelle
A1 Cross, Amanda J
A1 Vineis, Paolo
A1 Scalbert, Augustin
K1 Colorectal cancer
K1 Diet
K1 EPIC
K1 Intake
K1 Polyphenols
K1 Prospective cohort
AB Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.
YR 2018
FD 2018-05-15
LK http://hdl.handle.net/10668/12467
UL http://hdl.handle.net/10668/12467
LA en
DS RISalud
RD Apr 9, 2025