RT Generic T1 Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications? A1 Sanchez-Mata, Alicia A1 Gonzalez-Munoz, Elena K1 Mesenchymal stem-cells K1 Endometrial stem/progenitor cells K1 Side-population cells K1 Bone-marrow K1 Chondrogenic differentiation K1 Markers K1 Model K1 Transplantation K1 Decidualization K1 Proliferation AB Cells with mesenchymal stem cell properties have been identified in menstrual blood and termed menstrual blood-derived stem/stromal cells (MenSCs). MenSCs have been proposed as ideal candidates for cell-based therapy in regenerative medicine and immune-related diseases. However, MenSCs identity has been loosely defined so far and there is controversy regarding their cell markers and differentiation potential. In this review, we outline the origin of MenSCs in the context of regenerating human endometrium, with attention to endometrial eMSCs as reference cells to understand " SCs. We summarize the cell identity markers analyzed and the immunomodulatory and reparative properties reported. We also address the recent use of MenSCs in cell reprogramming. The main goal of this review is to contribute to the understanding of the identity and properties of MenSCs as well as to identify potential caveats and new venues that deserve to be explored to strengthen their potential applications. PB Cell press YR 2021 FD 2021-12-17 LK https://hdl.handle.net/10668/26678 UL https://hdl.handle.net/10668/26678 LA en DS RISalud RD Apr 18, 2025