RT Journal Article
T1 Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome.
A1 Rocha, Milagros
A1 Apostolova, Nadezda
A1 Diaz-Rua, Ruben
A1 Muntane, Jordi
A1 Victor, Victor M
K1 autophagy
K1 endoplasmic reticulum stress
K1 inflammasome
K1 mitochondria
K1 oxidative stress
K1 type 2 diabetes
AB Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its numerous clinical complications are related to mitochondrial dysfunction and oxidative stress. Over the past decade, great progress has been made in extending our knowledge about the signaling events regulated by mitochondria. However, the links among mitochondrial impairment, oxidative stress, autophagy, endoplasmic reticulum (ER) stress, and activation of the inflammasome still need to be clarified. In light of this deficit, we aim to provide a review of the existing literature concerning the complicated crosstalk between mitochondrial impairment, autophagy, ER stress, and the inflammasome in the molecular pathogenesis of T2D.
YR 2020
FD 2020-04-04
LK http://hdl.handle.net/10668/15340
UL http://hdl.handle.net/10668/15340
LA en
DS RISalud
RD Jun 16, 2025