TY - JOUR AU - Gonzalez-Rodriguez, Patricia AU - Zampese, Enrico AU - Stout, Kristen A AU - Guzman, Jaime N AU - Ilijic, Ema AU - Yang, Ben AU - Tkatch, Tatiana AU - Stavarache, Mihaela A AU - Wokosin, David L AU - Gao, Lin AU - Kaplitt, Michael G AU - Lopez-Barneo, Jose AU - Schumacker, Paul T AU - Surmeier, D James PY - 2021 DO - 10.1038/s41586-021-04059-0 UR - https://hdl.handle.net/10668/27577 T2 - Nature AB - Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson's disease1. Yet, whether this change contributes to Parkinson's disease pathogenesis is unclear2. Here we used... LA - en PB - Nature Publishing Group KW - Animals KW - Dendrites KW - Dopamine KW - Female KW - Mice KW - Parkinsonian Disorders KW - Substantia Nigra KW - Axons KW - Cell Death KW - Disease Models, Animal KW - Disease Progression KW - Dopaminergic Neurons KW - Electron Transport Complex I KW - Levodopa KW - Male KW - Motor Skills KW - NADH Dehydrogenase KW - Phenotype TI - Disruption of mitochondrial complex I induces progressive parkinsonism. TY - research article VL - 599 ER -