RT Journal Article
T1 Prognostic and Clinicopathological Significance of FADD Upregulation in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
A1 González-Moles, Miguel Ángel
A1 Ayén, Ángela
A1 González-Ruiz, Isábel
A1 de Porras-Carrique, Teresa
A1 González-Ruiz, Lucía
A1 Ruiz-Ávila, Isábel
A1 Ramos-García, Pablo
K1 FADD
K1 Fas-associated death domain
K1 Head and neck squamous cell carcinoma
K1 Oral squamous cell carcinoma
K1 Laryngeal squamous cell carcinoma
K1 Prognosis
K1 Biomarker
K1 Systematic review
K1 Meta-analysis
K1 Proteína de dominio de muerte asociada a Fas
K1 Carcinoma de células escamosas de cabeza y cuello
K1 Pronóstico
K1 Biomarcadores
K1 Revisión sistemática
K1 Metaanálisis
AB Fas-associated death domain (FADD) upregulation, i.e., gene amplification, protein phosphorylation and/or overexpression, has shown promising prognostic implications in head and neck squamous cell carcinoma (HNSCC). This systematic review and meta-analysis aims to evaluate the clinicopathological and prognostic significance of FADD upregulation in HNSCC. We searched studies published before February 2020 through PubMed, Embase, Web of Science, Scopus and Google Scholar. We evaluated the quality of the studies included using the QUIPS tool. The impact of FADD upregulation on survival and clinicopathological variables was meta-analysed. We explored heterogeneity and their sources, conducted sensitivity analyses and investigated small-study effects. Thirteen studies (1,923 patients) met inclusion criteria. FADD immunohistochemical overexpression was statistically associated with worse overall survival (hazard ratio [HR] = 1.52, 95% confidence intervals [CI] = 1.28-1.81, p < 0.001), disease-specific survival (HR = 2.52, 95% CI = 1.61-3.96, p < 0.001), disease-free survival (HR = 1.67, 95% CI=1.29-2.15, p < 0.001), higher clinical stage (odds ratio [OR] = 1.72, 95% CI = 1.17-2.51, p = 0.005) and a large magnitude of effect with N+ status (OR = 2.36, 95% CI = 1.85-3.00, p < 0.001). FADD phosphorylation in ser-194 demonstrated no prognostic value, while no conclusive results can be drawn for FADD gene amplification. In conclusion, our findings indicate that immunohistochemical assessment of FADD overexpression could be incorporated into the prognostic evaluation of HNSCC.
PB MDPI
YR 2020
FD 2020-08-24
LK http://hdl.handle.net/10668/3604
UL http://hdl.handle.net/10668/3604
LA en
NO González-Moles MA, Ayén A, González-Ruiz I, de Porras-Carrique T, González-Ruiz L, Ruiz-Ávila I, et al. Prognostic and Clinicopathological Significance of FADD Upregulation in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Cancers. 2020 Aug 24;12(9):2393
DS RISalud
RD Apr 9, 2025